MUbio presents a portofolio of antibodies to the most relevant intermediate filament proteins present in astrocytes,

23/02/2010
Astroglial cells are the most present cells in the mammalian central nervous system, yet our knowledge about their function in health and disease is still limited. In these cells intermediate filament (IF) networks constitute dynamic scaffolds integrating the cytoplasm on a structural and functional level.
Astrocyte precursors contain vimentin, nestin and synemin. As astrocytes differentiate, these IF proteins are replaced progressively by GFAP.

Since GFAP is the principal astrocyte intermediate filament protein, dominant mutations in the GFAP gene have been shown to lead to several central nervous system pathologies.

MUbio provides a portofolio of antibodies to the most relevant IF proteins present in mature, normally differentiating and diseased astrocytes, which can be applied in immunohistochemical and immunoblotting studies.

MUbio

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